C2C12 cells are a mouse myoblast cell line, originally obtained through serial passage of myoblasts cultured from the thigh muscle of C3H mice after a crush injury. Capable of differentiation, C2C12 cells can be used to study the differentiation of myoblast and osteoblast. These cells express receptors responsive to the TGFβ superfamily, and are useful for examining both TGFβ and BMP-mediated Smad signaling.
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