Scientific publications 2008

Arner P, Pettersson A, Mitchell PJ, Dunbar JD, Kharitonenkov A, Ryden M. (2008) FGF21 attenuates ipolysis in human adipocytes – A possible link to improved insulin sensitivity. FEBS Lett. 582, 1725-1730. Link to article.

Binder C, Lafayette A, Archibeque I, Sun Y, Plewa C, Sinclair A, Emkey R (2008) Optimization and utilization of the surefire phosphor-Stat5 assay for a cell-based screening campaign. Assay Drug Dev. Tech. 6, 27-37. Link to article.

Crouch MF, Osmond RIW (2008) New strategies in drug discovery for GPCRs: High throughput detection of cellular ERK phosphorylation. Comb. Chem High Thoughput Screen. 11, 344-356. Link to article.

Ferguson GM, Valant C, Horne J, Figler H, Flynn BL, Linden J, Chalmers DK, Sexton PM, Christopoulos A, Scammells PJ (2008) 2-Aminothienopyridazines as novel adensosine A1 receptor allosteric modulators and antagonists. J. Med Chem, 51, 6165-6172. Link to article.

Morfis M, Tilakaratne N, Furness SGB, Christopoulos C, Werry TD, Christopoulos A, Sexton PM (2008) Receptor activity modifying proteins differentially modulate the G protein-coupling efficiency of Amylin receptors. Endocrinology, 149, 5423-5431. Link to article.

Nawaratne V, Leach K, Suratman N, Loiacono RE, Felder CC, Armbruster BN, Roth BL, Sexton PM, Christopoulos A (2008) New insights into the function of M4 muscarinic acetylcholine receptors gained using a novel allosteric modulator and a DREADD (Designer Receptor Activated by a Designer Drug). Mol. Pharmacol. 74, 1-13. Link to article.

Roduit R, Schorderet DF. (2008) MAP kinase pathways in UV-induced apoptosis of retinal pigment epithelium ARPE19 cells. Apoptosis, 13, 343-353. Link to article.

Siehler S. (2008) Cell based assays in GPCR drug discovery. Biotechnol. J. 3, 471-483. Link to article.

Thor D, Schulz A, Hermsdorf T, Schoneberg T (2008) Generation of an agonistic binding site for blockers of the M3 muscarinic acetylcholine receptor. Biochem J, 412, 103-112. Link to article.

Valant C, Gregory KJ, Hall NE, Scammells PJ, Lew MJ, Sexton PM, Christopoulos A (2008)
A Novel Mechanism of G Protein-coupled Receptor Functional Selectivity: muscarinic partial agonist McN-A-343 as a bitopic orthosteric/allosteric ligand. J. Biol. Chem., 283: 29312 – 29321. Link to article.

Werry TD, Stewart GD, Crouch MF, Watts A, Sexton PM, Christopoulos A (2008) Pharmacology of 5HT2C receptor-mediated ERK1/2 phosphorylation: agonist specific activation pathways and the impact of RNA editing. Biochem. Pharmacol. 76, 1276-1287. Link to article.

Last updated: September 2011